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Chemistry in spaaaaace

An experiment sent engineered plants to the International Space Station.

If humanity is going to push the boundaries of space exploration, we’re going to need plants to come along for the ride. Not just spinach or potatoes, though—plants can do so much more than just feed us.

PHOTO CREDIT: Dave Titensor, University of Utah

Ming Hammond, associate professor of chemistry.

A science experiment aiming to demonstrate plants’ capabilities in space is at the International Space Station and is ready to begin relaying data. The experiment, according to University of Utah chemistry professor and project chief scientist Ming Hammond, assesses in real-time whether plants engineered to bio-manufacture specific proteins, in a process called synthetic biology, can do so in space. The experiment ran from Dec. 18-28, 2018.

“There’s a lot of promise, potential and hope that we can use the tools developed in synthetic biology to solve problems,” Hammond said, “not just that you would find in space, but where you have extreme limitation of resources.”

Hammond’s involvement in this experiment, called Hydra-1, began at the University of California, Berkeley, before her recent move to the U. She and Berkeley graduate student Rebekah Kitto joined with a “very multidisciplinary team”, Hammond said, of scientists and engineers looking to perform synthetic biology experiments in space.

Synthetic biology is a field that engineers biological systems. In this case, the team is looking at plants as potential bio-factories. Every organism naturally produces countless proteins as part of its biological function, so why not engineer a plant to produce, say, a needed medication or a polymer that could be useful in future long-term space exploration missions?

PHOTO CREDIT: Mathew Crawley, University of Utah College of Science

Seed storage units in the Plant Cube.

“The benefit is that you can take seeds with you,” Hammond said. “They’re very lightweight. They grow and gain biomass using the COthat we breathe out. And if those plants can produce proteins on demand—we know that plants are able to produce anti-viral and anti-cancer antibodies on a large scale.”

Synthetic biology is already established on Earth. But translating that same technology to spaceflight requires a different set of considerations. Hammond and her team encountered many of these constraints when adapting their experiment to operate within a small cube-shaped enclosure, and without tending from the space station crew. The enclosure is the same size (10 cm on a side) as the small low-cost CubeSats that are rising in popularity.

For an experiment on Earth, researchers could test samples of plants as they grew to see if they were producing the desired protein. But that’s not an option in space—in the early stages of planning, the team didn’t even know if they’d get the experiment back at the end.

So the team decided to engineer plants to change color as they produced the target protein, and monitor the progress with a camera. It’s an elegant and innovative solution, based on a previously published method, but adapted for the constraints of a cube in space.

PHOTO CREDIT: Ming Hammond

Members of the Hydra-1 team. Left to right, Yadvender Dhillon, Rebekah Kitto, Ming Hammond and James Bevington.

“We had to take something that worked beautifully in the most carefully controlled and nurturing conditions,” Hammond said, “and get it to work under very stringent, harsh and challenging conditions without human intervention in the plant cube.” The plant cube was designed with the forward vision of preparing for plant growth studies on the moon, and the Hydra-1 mission is a technology development step towards that goal.

The team of collaborators spans two continents, with other partners at NASA Ames Research Center, the International Space University and the University of Strasbourg. But as one of the experiment’s lead scientists, Hammond monitored data from the experiment and conducted the matching Earthbound control experiment, here at the University of Utah. The control experiment grew the same plants, engineered to produce the same protein, but lagged behind the experiment on the space station by one day so researchers could match both experiments’ temperature conditions.

The entire experiment took 10 days. Speaking of the experiment beforehand, Hammond said, “By day four or five we should know if the experiment worked. There are so many variables that we can’t know the answers to.” This month, the cube will return to Earth and will be further analyzed in Strasbourg. “I plan for this experience to prepare us for doing more chemistry experiments in space!” Hammond said.

PHOTO CREDIT: Mathew Crawley, University of Utah College of Science

The LED lights used to grow engineered plants in the plant cube, with a camera in the center relaying images of the plants to the Earth-based science team.

On the engineering side, the Hydra-1 experiment should help develop a framework, through a commercial company called ICE-Cubes, to commercialize similar cube-based space science experiments in the future.

It takes a lot of time and effort to put equipment in space, and Hammond appreciates the many hours of work that the team has put in over the past two years. “We are a small but dedicated group of volunteers,” she said. “In the past two weeks, people worked nonstop to fix last-minute things that came up before launch. I’m just really proud of the effort that everyone has undertaken to get us to this point.”

Hammond and her family traveled to the NASA Kennedy Space Center to watch the Dec. 5 launch of her experiment, which was nestled within a SpaceX Falcon 9 rocket on a resupply mission to the International Space Station. “I think most of us feel the allure and excitement that is stirred by the wonder of looking up and thinking about humans living and working at the space station,” she said. “It was an amazing opportunity to share the launch with my 6-year-old son and other family members. Of all the things I’ve done in science this, for them, is the one that probably inspires the most interest and awe.”

Read the International Space University’s release here.

Be sure to check back for more on this experiment and its results in future issues of @theU.