View the original post from University of Utah Health here.

Late-stage failure of the left side of the heart is an often fatal condition affecting hundreds of thousands of people in the U.S. A mechanical heart pump can be a lifesaving intervention for such patients, but the surgery to implant the pump is risky. One of the most serious risks is right heart failure, in which the right side of the heart becomes unable to pump enough blood to the lungs. Identifying patients who have a high risk of right heart failure can help doctors better prepare patients for heart pump placement. But predicting who is most at risk has proven difficult.

A nationwide team led by researchers at University of Utah Health has now developed a way to predict a patient’s individualized risk of right heart failure following surgery to place the pump. The team is now using this risk calculator to tailor care to each patient before and during heart pump placement. Their results are published in JAMA Cardiology.

Finding the needle in the data haystack

For people who undergo surgery to implant a left heart pump, the risk of subsequent right heart failure is high, around 15 to 30%. But the large number of factors that contribute to an individual’s risk of right heart failure make personalized risk prediction “exceptionally difficult,” said Iosif Taleb, a cardiology fellow at the University of California, San Diego and first author on the study. Taleb helped develop the risk calculator during his clinical research fellowship at U of U Health. 

“Each patient is unique with different health conditions and heart characteristics,” Taleb said. “Heart pumps also have specific traits, and the combination of these factors makes predictions tough.”

Stavros Drakos, professor of cardiology at U of U Health and senior author on the publication said that past efforts tried to predict which patients should get a heart pump [also called a left ventricular assist device, or LVAD] and which should not, but these attempts didn’t perform well in the real world. Even models that seemed to predict outcomes in one hospital often failed to give accurate predictions in another.

Aiming to develop a more accurate and broadly usable risk calculator, the researchers used data from 1,125 patients across six health centers, including U of U Health. Taking into account variables ranging from pre-existing health conditions to medications and demographic information, they used machine learning to generate and test many models of risk and find the one that best described patients’ health outcomes.

Their model identified several variables that are especially useful when predicting whether a patient will develop right heart failure (RVF), such as whether patients needed additional forms of heart support before their initial surgery to better prepare them and lead to better outcomes. The researchers used these factors to develop an easy-to-use online calculator that determines a patient’s percent risk of right heart failure after surgery.

The new risk calculator, called STOP-RVF, describes individual risk more accurately than earlier models. It also works well in a variety of situations. The researchers checked the calculator’s accuracy by using it to calculate risks retrospectively for patients in another hospital system. The scientists then compared the calculator’s predictions to the patients’ real-world outcomes, finding that their tool was still able to accurately model patients’ risk of subsequently developing right heart failure.

Predicting outcomes nationwide

Building the model on data from a large and diverse population was essential to accurately describe risk for patients nationwide.

“It’s important because we live in a very diverse country,” Drakos said. “By basing this analysis in multiple sites all over the country—the Washington, D.C., area, the Detroit area, California, Utah, and the broader Mountain West—it’s representative of a large part of our country. It strengthens the generalizability of the work.”

The cardiologists, surgeons and nurse coordinators of the heart failure and LVAD team at U of U Health have already started using the calculator in their clinical practice to personalize care.

“It helps tailor the risk assessment for each patient, allowing for better preparation before surgery,” Taleb explained. For patients who have a high risk of right heart failure, doctors can delay the surgery, use different medications to improve patients’ odds of recovery or consider alternative treatments.

It remains too early to say whether the calculator will improve patient outcomes. However, Drakos expects that it will be more useful than previous models because it was developed using patient populations from multiple hospitals.

“We validated it in other hospitals, and it performed very well,” he said. “But of course, time will tell how significant its impact on patient outcomes will be.”